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Symbol
Name
ID

Smad3
SMAD family member 3
MGI:1201674

Phenotype annotations related to reproductive system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Cystocele	Ovarian neoplasm	Ovarian carcinoma	Endometrial carcinoma	Uterine prolapse
Disease(s) Associated with SMAD3	Cystocele	Ovarian neoplasm	Ovarian carcinoma	Endometrial carcinoma	Uterine prolapse
Loeys-Dietz syndrome 3
Lynch syndrome
pancreatic cancer

Mouse Phenotypes		reproductive system phenotype	decreased primary ovarian follicle number	increased primordial ovarian follicle number	decreased secondary ovarian follicle number	decreased tertiary ovarian follicle number	impaired ovarian folliculogenesis	reduced female fertility	abnormal fertility/fecundity
Availability	Mouse Genotype	reproductive system phenotype	decreased primary ovarian follicle number	increased primordial ovarian follicle number	decreased secondary ovarian follicle number	decreased tertiary ovarian follicle number	impaired ovarian folliculogenesis	reduced female fertility	abnormal fertility/fecundity
	Smad3^tm1Cxd/Smad3^tm1Cxd
	Smad3^tm1Par/Smad3^tm1Par
	Amhr2^tm3(cre)Bhr/Amhr2⁺ Smad3^tm1Par/Smad3^tm1Zuk (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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